Tried to enable multidex in every single way in my project, without success, my app was crashing when trying to use firebase in my app, always threw class not found exception, so untill I disable card view library, it worked again, but when I tried to add one more method (just setting ID to my edittext) it threw same error, so to keep working in aide (because is easy and you can develop anytime) Found out that to reduce un-needed methods we can stop using references as strings.xml the less references you have there is better, also in colors.xml , un-needed drawables (delete them) , in styles xml as well avoid using them. Just write values directly to your view in xml.
Any others ideas based on your experience are welcome !!!